Rat

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Mouse/Rat RANTES (RANTES / CCL5)
300-607

 Regulated upon activation, normal T cell expressed and secreted (RANTES), also called CCL5, is a chemokine produced by T cells three to five days after T cell activation. RANTES signals through G protein-coupled receptors CCR5, CCR3, CCR1, and through the human CMV-encoded viral receptor US28. RANTES functions to recruit immune cells to inflammatory sites.

Ships ambient. Store frozen at -20 to -10C.

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Human/Mouse/Rat Growth and Differentiation Factor-11 (GDF-11)
300-603

 Growth differentiation factor 11 (GDF-11), also known as bone morphogenetic protein 11 (BMP-11), is a regulator of cell growth and differentiation during muscular and neural development. GDF-11 binds the transforming growth factor-beta receptors ALK4, ALK5, and ALK7 to activate SMAD signaling. In adults, exogenous GDF-11 promotes cardiomyocyte regeneration to reverse age-related cardiac hypertrophy.

Ships ambient. Store frozen at -20 to -10C.

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Human/Mouse/Rat Bone Morphogenetic Protein-2 (BMP-2)
300-601

Bone morphogenetic protein 2 (BMP-2 or BMP2) is a member of the bone morphogenetic protein (BMP) family and functions as a potent inducer of bone and cartilage development. BMP proteins are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. Bioactive BMP-2 consists of forming a homodimer or a heterodimer with a related BMP, such as BMP-7. BMP-2 signals through type I and type II receptor tyrosine kinases in conjuction with SMAD proteins to directly promote osteoblast differentiation.

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Human/Mouse/Rat Activin A
300-600

Activin A is a member of the transforming growth factor beta (TGF-β) family of proteins and functions to stimulate follicle-stimulating hormone (FSH) secretion.  Activins are produced in many tissue types including the skin, gonads, lungs, and pituitary gland.  Activins interact with receptor type I and type II serine/threonine protein kinases, to activate SMAD signaling and regulate diverse cellular functions, such as cell proliferation, differentiation, wound healing, apoptosis, and metabolism.  Activin A is a homodimer comprised of two activin βA chains.

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Rat Sonic Hedgehog (SHH)
300-527P

 Sonic hedgehog (SHH) is a member of a small group of hedgehog secreted proteins that are essential for development in both vertebrates and invertebrates.  There are three mammalian hedgehog homologues, sonic, desert, and indian, that signal via the Patched-1 and Patched-2 receptors.  SHH is a morphogen that is essential during vertebrate organogenesis and adult stem cell division. 

Ships ambient. Store frozen at -20 to -10C.

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Rat Interleukin-3 beta (IL-3 beta)
300-526P

Interleukin 3 beta (IL-3 β) is a cytokine that is produced by activated T cells and mast cells.  IL-3 β induces the differentiation of hematopoietic stem cells into myeloid precursor cells, such as erythrocyte, megakaryocyte, granulocyte, monocyte, and dendritic cells.  IL-3 β also functions in the nervous system and is important during the B-1 cell regulation of chronic inflammatory diseases. 

Ships ambient. Store frozen at -20 to -10C.

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Rat Interleukin-2 (IL-2)
300-525P

 Interleukin 2 (IL-2) is an immunomodulatory cytokine that is produced by lymphocytes.  IL-2 signals through the IL-2R receptor to induce activated T cell proliferation and promote T cell differentiation. IL-2 also stimulates the proliferation and differentiation of B cells, natural killer cells, monocytes, and macrophages.

Ships ambient. Store frozen at -20 to -10C.

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Rat Interleukin-10 (IL-10)
300-524P

 Interleukin 10 (IL-10) is an anti-inflammatory cytokine produced by macrophages and type 2 T helper (Th2) cells. IL-10 inhibits the production of pro-inflammatory cytokines such as interferon gamma (IFNƴ), tumor necrosis factor alpha (TNFα), interleukin 2 (IL-2), interleukin 3 (IL-3), interleukin 4 (IL-4), and granulocyte-macrophage colony-stimulating factor (GM-CSF), made by macrophages and regulatory T cells. IL-10 also suppresses antigen presentation on antigen presenting cells, and enhances the survival, proliferation, and antibody production of B cells.

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Rat Epidermal Growth Factor (EGF)
300-518P

Epidermal Growth Factor (EGF) is a growth factor that stimulates the proliferation of epithelial and epidermal cells. EGF family members are characterized by three intramolecular disulfide bonds and can bind to four different receptor tyrosine kinases known as EGFR/ErbB1, ErbB2, ErbB3, and ErbB4. Recombinant rat EGF is a non-glycosylated protein, containing 54 amino acids, with a molecular weight of 6.3 kDa.

Ships ambient. Store frozen at -20 to -10C.

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Rat Fibroblast Growth Factor-9 (FGF-9)
300-500P

Fibroblast growth factor-9 (FGF-9) is a steroid-regulated mitogen and survival factor for nerve and mesenchymal cells. FGF-9 is an autocrine/paracrine growth factor considered to be important for the growth and survival of motorneurons and prostate tissue.  Recombinant rat FGF-9 is a non-glycosylated protein, containing 205 amino acids and has a molecular mass of 23.3 kDa.

Ships ambient. Store frozen at -20 to -10C.

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Rat Fibroblast Growth Factor-basic (FGF-basic)
300-520P

Fibroblast Growth Factors (FGFs) are a 22 member family of proteins known to be involved in angiogenesis, wound healing and embryonic development. As a family, they bind to heparin and signal through four receptor tyrosine kinases called, FGFR1, 2, 3 and 4. Recombinant rat FGF-basic is a non-glycosylatedprotein, containing 146 amino acids, with a molecular weight of 16.4 kDa.

Ships ambient. Store frozen at -20 to -10C.

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Rat Fibroblast Growth Factor-basic (FGF-basic) – Animal Free
300-804P

Fibroblast Growth Factors (FGFs) are a 22 member family of proteins known to be involved in angiogenesis, wound healing and embryonic development. As a family, they bind to heparin and signal through four receptor tyrosine kinases called, FGFR1, 2, 3 and 4. Recombinant rat FGF-basic is a non-glycosylatedprotein, containing 146 amino acids, with a molecular weight of 16.4 kDa.

This product is produced using Animal Free raw components and processes, in a non-mammalian system.

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Rat Glial Derived Neurotrophic Factor (Animal Free)
300-831P

Glial Cell Line-Derived Neurotrophic Factor, or GDNF, is a neurotrophic factor that is closely related to other neurotrophic factors such as Neurturin, Persephin, and Artemin, by a common structural feature called the cysteine-knot. GDNF signals through a multicomponent system of receptors that includes receptors known as RET, and GFRα1-4 to promote dopamine uptake, survival and differentiation of neurons.  Recombinant rat GDNF is a non-glycosylated homodimer, containing two 135 amino acid chains, with a total molecular weight of 30.1 kDa.

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Rat Glial Derived Neurotrophic Factor (GDNF)
300-521P

Glial Cell Line-Derived Neurotrophic Factor, or GDNF, is a neurotrophic factor that is closely related to other neurotrophic factors such as Neurturin, Persephin, and Artemin, by a common structural feature called the cysteine-knot. GDNF signals through a multicomponent system of receptors that includes receptors known as RET, and GFRα1-4 to promote dopamine uptake, survival and differentiation of neurons.  Recombinant rat GDNF is a non-glycosylated homodimer, containing two 135 amino acid chains, with a total molecular weight of 30.1 kDa.

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Rat Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF)
300-501P

Granulocyte Macrophage Colony Stimulating Factor, GM-CSF, is hematopoietic factor produced by endothelial cells, monocytes, fibroblasts and T cells in response to a number of inflammatory mediators. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells.

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Rat Insulin Like Growth Factor I (IGF-I)
300-502P

Insulin-like Growth Factor I, IGF-I, is a growth factor produced in response to growth hormone-stimulated liver and can be found circulating throughout the body and throughout life. IGF-I activates the IGF-I receptor (IGF1R) and the insulin receptor to mediate growth of almost every cell of the body.

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Rat Interferon gamma (IFN-γ)
300-503P

Interferon gamma, IFN-γ, is a major immune-modulating molecule produced mainly by T-cells and natural killer cells activated by antigens, mitogens or alloantigens. Most immune cells express IFN-γ receptors and respond to IFN-γ-induced signaling by up-regulating MHC class I expression. Recombinant rat  IFN gamma is a non-glycosylated protein, containing 135 amino acids and has a predicted molecular weight of 15.6 kDa.

Ships ambient. Store frozen at -20 to -10C.

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Rat Interleukin-1 beta (IL-1 β)
300-504P

Interleukin-1 beta (IL-1β) is a proinflammatory cytokine, produced in response to inflammatory agents by a variety of cells, including, monocytes, macrophages, and dendritic cells (DCs). IL-1β and IL-1α are two distinct and independently regulated gene products that comprise IL-1 and signal through the Type 1 IL-1 receptor (IL-1R1).

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Rat Interleukin-17A (IL-17A)
300-505P

Interleukin-17A (IL-17A), also known as CTLA-8, is a pro-inflammatory cytokine member of a six-species family of proteins (IL-17A-17F).   IL-17A is secreted mainly by activated  CD4+ and CD8+ T lymphocytes and acts through its receptor, IL-17R, to induce the expression of many mediators of inflammation, most importantly, those that are involved in the proliferation, maturation and chemotaxis of neutrophils.  Elevated levels of IL-17A have been associated with several conditions, including rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory boweld

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Rat Interleukin-17AF Heterodimer (IL-17AF Heterodimer)
300-506P

Interleukin-17AF (IL-17AF) is a member of the IL-17 family of proteins produced by a subset of T cells, called Th17, following stimulation with IL-23. Since IL-17AF is thought to signal through the IL-17RA receptor, its biological function is similar to that of IL-17A in that it induces the production of a variety of chemokines, in addition to airway neutrophilia.

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