Mouse

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Mouse/Rat RANTES (RANTES / CCL5)
300-607

 Regulated upon activation, normal T cell expressed and secreted (RANTES), also called CCL5, is a chemokine produced by T cells three to five days after T cell activation. RANTES signals through G protein-coupled receptors CCR5, CCR3, CCR1, and through the human CMV-encoded viral receptor US28. RANTES functions to recruit immune cells to inflammatory sites.

Ships ambient. Store frozen at -20 to -10C.

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Human/Mouse Transforming Growth Factor-beta 3 (TGF-β 3)
300-606

Transforming growth factors (TGFs) are multifunctional peptides that regulate growth and differentiation in most cell types. The TGF-β family of proteins signal through serine/threonine kinase receptors. TGF-β isoforms (TGF-β1, -β2, and –β3) have overlapping, yet distinct biological actions in developing and adult tissues. TGF-β3 is an important factor in regulating cell adhesion and accelerating wound repair. TGF-β3 also functions during osteoblast proliferation, chemotaxis, and collagen synthesis.

Ships ambient. Store frozen at -20 to -10C.

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Human/Mouse Neurotrophin-3 (NT-3)
300-605

Neurotrophin-3 (NT-3) is an important member of the nerve growth factor (NGF) family of proteins. NT-3 promotes the growth, survival, and differentiation of neurons and synapses in the peripheral and central nervous systems. The receptor tyrosine kinase TrkC exclusively binds in high-affinity to NT-3. NT-3 also signals through the receptor tyrosine kinase TrkB, and through the low affinity nerve growth factor receptor (LNGFR).

Ships ambient. Store frozen at -20 to -10C.

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Human/Mouse Indian Hedgehog (IHH)
300-604

Indian hedgehog (IHH) is an essential signaling factor that is secreted in the gut, cartilage, and bone during embryonic development. IHH acts through the patched (PTC) receptor to induce transcriptional changes important for bone and cartilage development. IHH also induces the expression of parathyroid hormone-related peptide (PTHrP), which in turn mediates IHH activity during chondrocyte differentiation, forming a negative feedback loop.

Ships ambient. Store frozen at -20 to -10C.

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Human/Mouse/Rat Growth and Differentiation Factor-11 (GDF-11)
300-603

 Growth differentiation factor 11 (GDF-11), also known as bone morphogenetic protein 11 (BMP-11), is a regulator of cell growth and differentiation during muscular and neural development. GDF-11 binds the transforming growth factor-beta receptors ALK4, ALK5, and ALK7 to activate SMAD signaling. In adults, exogenous GDF-11 promotes cardiomyocyte regeneration to reverse age-related cardiac hypertrophy.

Ships ambient. Store frozen at -20 to -10C.

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Human/Mouse Fibroblast Growth Factor-8 (FGF-8)
300-602

Fibroblast growth factor 8 (FGF-8) is a critical mitogenic factor that is required for normal development of the eye, ear, brain, and limb. FGF-8 functions broadly to promote cell proliferation, differentiation, and migration. Overexpression of FGF-8 increases tumor growth and angiogenesis. Human and mouse FGF-8 proteins show 100% homology.

Ships ambient. Store frozen at -20 to -10C.

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Human/Mouse/Rat Bone Morphogenetic Protein-2 (BMP-2)
300-601

Bone morphogenetic protein 2 (BMP-2 or BMP2) is a member of the bone morphogenetic protein (BMP) family and functions as a potent inducer of bone and cartilage development. BMP proteins are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. Bioactive BMP-2 consists of forming a homodimer or a heterodimer with a related BMP, such as BMP-7. BMP-2 signals through type I and type II receptor tyrosine kinases in conjuction with SMAD proteins to directly promote osteoblast differentiation.

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Human/Mouse/Rat Activin A
300-600

Activin A is a member of the transforming growth factor beta (TGF-β) family of proteins and functions to stimulate follicle-stimulating hormone (FSH) secretion.  Activins are produced in many tissue types including the skin, gonads, lungs, and pituitary gland.  Activins interact with receptor type I and type II serine/threonine protein kinases, to activate SMAD signaling and regulate diverse cellular functions, such as cell proliferation, differentiation, wound healing, apoptosis, and metabolism.  Activin A is a homodimer comprised of two activin βA chains.

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Mouse RELM-gamma (RELM γ)
300-382P

  Resistin-like molecule-gamma (RELM-γ) is a member of the RELM family of secreted proteins containing C-terminal cysteines. The RELM family consists of Resistin (FIZZ3), RELM-α (FIZZ1), RELM-β (FIZZ2), and RELM-γ (FIZZ4). RELM-γ is secreted by peripheral blood granulocytes, bone marrow, spleen, intestine, and lung. RELM-γ functions to promote and regulate promyelocytic differentiation, in addition to regulating nutrient-associated insulin sensitivity in the intestinal tract.

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Mouse Interleukin-1 alpha (IL-1α / IL-1F1)
300-381P

Interleukin 1 alpha (IL-1α) is expressed by epithelial cells, activated macrophages, neutrophils, and endothelial cells to regulate immune responses. IL-1α signals through the IL-1 receptor, type 1 (IL-1R1) to activate the myeloid differentiation primary response 88 (MYD88) signaling pathway, which contains the cytoplasmic Toll/IL-1 receptor (TIR) domain adapter.

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Mouse Insulin-like Growth Factor II (IGF-II)
300-380P

Insulin-like growth factor II (IGF-II) is an important fetal growth hormone made by theca cells during gestation.  IGF-II engages the IGF-I receptor (IGF1R) to mediate embryonic growth.  IGF-II also binds the sink IGF-II receptor (IGF2R) leading to IGF-II degradation. 

Ships ambient. Store frozen at -20 to -10C.

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Mouse Interleukin IL-10
300-379P

Interleukin 10 (IL-10) is an anti-inflammatory cytokine produced by macrophages and type 2 T helper (Th2) cells. IL-10 inhibits the production of pro-inflammatory cytokines such as interferon gamma (IFNƴ), tumor necrosis factor alpha (TNFα), interleukin 2 (IL-2), interleukin 3 (IL-3), interleukin 4 (IL-4), and granulocyte-macrophage colony-stimulating factor (GM-CSF), made by macrophages and regulatory T cells. IL-10 also suppresses antigen presentation on antigen presenting cells, and enhances the survival, proliferation, and antibody production of B cells.

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Mouse Interleukin-36 gamma (IL-36 γ)
300-377P

 Interleukin 36 gamma (IL-36 ɣ) is a member of the interleukin 1 (IL-1) cytokine family and protects against pathogens in the skin, lung, and stomach epithelial barriers. IL-36 ɣ binds the interleukin-1 receptor accessory protein (IL-1RAcP) and the orphan IL-1R-related protein 2 (IL-1Rrp2) receptors to activate NF-kB and MAP kinase signaling pathways, resulting in the induced production of inflammatory cytokines and chemokines.

Ships ambient. Store frozen at -20 to -10C.

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Mouse Macrophage Inflammatory Protein-2 (MIP-2 / CXCL2)
300-376P

Macrophage Inflammatory Protein 2 (MIP-2), also known as CXCL2, is a small cytokine that is secreted by monocytes and neutrophils at sites of inflammation. MIP-2 functions through the chemokine receptor CXCR2 to act as a chemotactic agent for leukocytes and hematopoietic cells. 

Ships ambient. Store frozen at -20 to -10C.

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Mouse CD40 Ligand
300-300P

CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells. The CD40-L stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40-L has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes.

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Product 5 μg $9020 μg $304

Mouse EGF-Biotin Conjugate
300-366

Epidermal Growth Factor (EGF) is a growth factor that stimulates the proliferation of epithelial and epidermal cells.  EGF family members are characterized by three intramolecular disulfide bonds and can bind to four different receptor tyrosine kinases known as EGFR/ErbB1, ErbB2, ErbB3, andErbB4.  This version of EGF has has a N terminal leader sequence hosting a biotin conjugation.  There is no significant decrease in biological activity for the biotin conjugate when compared to standard recombinant mouse EGF. 

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Product 100 µg $90500 µg $2071 Mg Inquire5 Mg Inquire

Mouse Epidermal Growth Factor (EGF)
300-301P

Epidermal Growth Factor (EGF) is a growth factor that stimulates the proliferation of epithelial and epidermal cells. EGF family members are characterized by three intramolecular disulfide bonds and can bind to four different receptor tyrosine kinases known as EGFR/ErbB1, ErbB2, ErbB3, and ErbB4. Recombinant mouse EGF is a non-glycosylated protein, containing 53 amino acids, including 3 intra-moleuclar disulfide-bonds and having a molecular mass of 6 kDa.

Ships ambient. Store frozen at -20 to -10C.

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Product 100 μg $98500 μg $2281 Mg Inquire5 Mg Inquire

Mouse Epidermal Growth Factor (EGF) – Animal Free
300-845P

Epidermal Growth Factor (EGF) is a growth factor that stimulates the proliferation of epithelial and epidermal cells.  EGF family members are characterized by three intramolecular disulfide bonds and can bind to four different receptor tyrosine kinases known as EGFR/ErbB1, ErbB2, ErbB3, and ErbB4.  Recombinant mouse EGF is a non-glycosylated protein, containing 53 amino acids, including 3 intra-molecular disulfide-bonds, with a molecular weight of 6 kDa.

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Mouse Epstein-Barr Virus Induced Gene 3 (IL-27 / EBI-3)
300-302P

Epstein-Barr Virus Induced Gene-3 (EBI3), is a secreted glycoprotein belonging to the hematopoietin receptor family and is related to the p40 subunit of IL-12.  EBI3 was identified by its induced expression in B-lymphocytes in response to Epstein-Barr virus infection.  EBI3 forms heterodimers with p28 to form IL-27 and with p35 to form IL-35.  Both IL-27 and IL-35 have anti-inflammatory and regulatory activity. Recombinant mouse EBI3 is a non-glycosylate protein, consisting of 207 amino acids with a molecular weight of 22.9 kDa.

Ships ambient.

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Mouse Exodus-2 (CCL21)
300-361P

Exodus-2, also known as CCL21 and 6Ckine, is a novel chemokine produced at high levels in human lymph node tissue and the spleen. 6Ckine signals through the CCR7 receptor to recruit thymocytes and activated T cells in vitro, but is not known to be chemotactic for monocytes. Human and mouse Exodus-2 share > 85% amino acid identity. Recombinant mouse Exodus-2 is a non-glycosylated protein, containing 110 amino acids, with a molecular weight of 12 kDa.

Five unit minimum required. Ships on dry ice. Store frozen at -20 to -10°C

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