The chemokine IP-10 (or CXCL10) is a chemokine made by monocytes, endothelial cells and fibroblasts in response to treatment with IFNγ. IP-10 functions as a chemoattractant cells expressing the G protein-coupled receptor, CXCR3, which is found mainly on activated T cells and NK cells. IP-10 plays an important role in Th1 type inflammatory diseases and autoimmune diseases such as, Hashimoto’s thyroiditis, Graves’ disease and Type 1 diabetes mellitus.Recombinant human IP-10 is a non-glycosylated protein, containing 77 amino acids and having a molecular mass of 8.5 kDa.
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