Human

Product 2 μg $9010 μg $207100 μg Inquire500 μg Inquire1Mg Inquire

Human/Feline Stromal Cell-Derived Factor-1 beta (SDF-1 β / CXCL12)
300-608

Stromal cell-derived factor-1 beta (SDF-1 β), also called CXCL12b, is one of two SDF-1 splice variants made by a wide variety of cells upon stimulation by inflammatory cytokines such as TNF, IL-1, and LPS. SDF-1 β signals through the G protein-coupled receptor CXCR4 to recruit activated leukocytes.

Ships ambient. Store frozen at -20 to -10C.

*Single-unit price. For inquiries about this product, contact your sales representative.

Product 2 μg $9010 μg $207100 μg Inquire500 μg Inquire1Mg Inquire

Human/Mouse Transforming Growth Factor-beta 3 (TGF-β 3)
300-606

Transforming growth factors (TGFs) are multifunctional peptides that regulate growth and differentiation in most cell types. The TGF-β family of proteins signal through serine/threonine kinase receptors. TGF-β isoforms (TGF-β1, -β2, and –β3) have overlapping, yet distinct biological actions in developing and adult tissues. TGF-β3 is an important factor in regulating cell adhesion and accelerating wound repair. TGF-β3 also functions during osteoblast proliferation, chemotaxis, and collagen synthesis.

Ships ambient. Store frozen at -20 to -10C.

*Single-unit price. For inquiries about this product, contact your sales representative.

Product 2 μg $9010 μg $207100 μg Inquire500 μg Inquire1Mg Inquire

Human/Mouse Neurotrophin-3 (NT-3)
300-605

Neurotrophin-3 (NT-3) is an important member of the nerve growth factor (NGF) family of proteins. NT-3 promotes the growth, survival, and differentiation of neurons and synapses in the peripheral and central nervous systems. The receptor tyrosine kinase TrkC exclusively binds in high-affinity to NT-3. NT-3 also signals through the receptor tyrosine kinase TrkB, and through the low affinity nerve growth factor receptor (LNGFR).

Ships ambient. Store frozen at -20 to -10C.

*Single-unit price. For inquiries about this product, contact your sales representative.

Product 5 μg $9025 μg $90100 μg Inquire500 μg Inquire1Mg Inquire

Human/Mouse Indian Hedgehog (IHH)
300-604

Indian hedgehog (IHH) is an essential signaling factor that is secreted in the gut, cartilage, and bone during embryonic development. IHH acts through the patched (PTC) receptor to induce transcriptional changes important for bone and cartilage development. IHH also induces the expression of parathyroid hormone-related peptide (PTHrP), which in turn mediates IHH activity during chondrocyte differentiation, forming a negative feedback loop.

Ships ambient. Store frozen at -20 to -10C.

*Single-unit price. For inquiries about this product, contact your sales representative.

Product 5 μg $9020 μg $207100 μg Inquire500 μg Inquire1Mg Inquire

Human/Mouse/Rat Growth and Differentiation Factor-11 (GDF-11)
300-603

 Growth differentiation factor 11 (GDF-11), also known as bone morphogenetic protein 11 (BMP-11), is a regulator of cell growth and differentiation during muscular and neural development. GDF-11 binds the transforming growth factor-beta receptors ALK4, ALK5, and ALK7 to activate SMAD signaling. In adults, exogenous GDF-11 promotes cardiomyocyte regeneration to reverse age-related cardiac hypertrophy.

Ships ambient. Store frozen at -20 to -10C.

*Single-unit price. For inquiries about this product, contact your sales representative.

Product 5 μg $9025 μg $207100 μg Inquire500 μg Inquire1Mg Inquire

Human/Mouse Fibroblast Growth Factor-8 (FGF-8)
300-602

Fibroblast growth factor 8 (FGF-8) is a critical mitogenic factor that is required for normal development of the eye, ear, brain, and limb. FGF-8 functions broadly to promote cell proliferation, differentiation, and migration. Overexpression of FGF-8 increases tumor growth and angiogenesis. Human and mouse FGF-8 proteins show 100% homology.

Ships ambient. Store frozen at -20 to -10C.

*Single-unit price. For inquiries about this product, contact your sales representative.

Product 2 μg $9010 μg $207100 μg Inquire500 μg Inquire1Mg Inquire

Human/Mouse/Rat Activin A
300-600

Activin A is a member of the transforming growth factor beta (TGF-β) family of proteins and functions to stimulate follicle-stimulating hormone (FSH) secretion.  Activins are produced in many tissue types including the skin, gonads, lungs, and pituitary gland.  Activins interact with receptor type I and type II serine/threonine protein kinases, to activate SMAD signaling and regulate diverse cellular functions, such as cell proliferation, differentiation, wound healing, apoptosis, and metabolism.  Activin A is a homodimer comprised of two activin βA chains.

*Single-unit price. For inquiries about this product, contact your sales representative.

Product 5 μg $9025 μg $207100 μg Inquire500 μg Inquire1Mg Inquire

Human Placenta Growth Factor-3 (PlGF-3)
300-251P

 Placenta growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family and promotes endothelial cell growth and angiogenesis.  PlGF is secreted as a homodimer and may also form a heterodimer with VEGF.  PlGF is detected in the placenta, heart, lungs, thyroid, and adipose tissues.  Circulating PlGF levels are correlated with colorectal and renal cancers, as well as atherosclerosis and ischemic heart disease.  There are four alternatively spliced PlGF isoforms (PlGF-1, PlGF-2, PlGF-3, and PlGF-4), each with unique secretion patterns and hep

*Single-unit price. For inquiries about this product, contact your sales representative.

Product 5 μg $9025 μg $207100 μg Inquire500 μg Inquire1Mg Inquire

Human Fibroblast Growth Factor-9 (FGF-9)
300-250P

 Fibroblast growth factor 9 (FGF-9) is a mitogen and survival factor for nerve and mesenchymal cells. FGF-9 functions as an autocrine and paracrine factor to support the growth and survival of motor neurons and prostate tissue. FGF-9 expression in the gonad is also necessary for sex determination. 

Ships ambient. Store frozen at -20 to -10C.

*Single-unit price. For inquiries about this product, contact your sales representative.

Product 5 μg $11320 μg $300100 μg Inquire500 μg Inquire1Mg Inquire

Human BMPR-1A / ALK-3, Fc Tag
300-249P

 Bone morphogenetic protein receptor type-1A (BMPR-1A) is a Type I receptor that complexes with BMP Type II receptors to activate SMAD signaling.  BMPR-1A is a receptor for BMP-2, BMP-4, GDF-5, and GDF-6.  This protein product contains the first 152 amino acids of the extracellular portion of BMPR-1A and can be used to interfere with or neutralize ligand signaling.  The product contains a C-terminus linker (IEGRMD) and an Fc tag (Human IgG1). 

Ships ambient. Store frozen at -20 to -10C.

*Single-unit price. For inquiries about this product, contact your sales representative.

Product 5 μg $9025 μg $207100 μg Inquire500 μg Inquire1Mg Inquire

Human Neutrophil Activating Peptide 2 (NAP-2 / CXCL7)
300-248P

Neutrophil activating peptide 2 (NAP-2), also known as CXCL7, is a member of the CXC family of chemokines. NAP-2 is a carboxyl-terminal fragment produced by proteolytic cleavage of the platelet basic protein (PBP). NAP-2 is released from platelets and binds to the receptors CXCR1 and CXCR2 to chemoattract and activate neutrophils during inflammatory events. 

Ships ambient. Store frozen at -20 to -10C.

*Single-unit price. For inquiries about this product, contact your sales representative.

Product 5 μg $9025 μg $207100 μg Inquire500 μg Inquire1Mg Inquire

Human R-Spondin 1
300-246P

 R-Spondin 1 (RSPO-1)is a secreted growth factor that stabilizes β-catenin and enhances WNT signaling.  RSPO-1 is expressed in many tissues and regulates female sex determination, XX gonad development, oocyte differentiation, and hematopoietic stem cell specification.  The RSPO-1 stabilization of β-catenin promotes intestinal crypt cell proliferation.  This suggests that RSPO-1 functions as a stem cell growth factor and may have therapeutic potential in the treatment of gastrointestinal diseases and chemotherapy-induced intestinal mucositis.  Additionally, recombina

*Single-unit price. For inquiries about this product, contact your sales representative.

Product 10 μg $9050 μg $207100 μg Inquire500 μg Inquire1Mg Inquire

Human Amphiregulin (AREG)
300-245P

 Amphiregulin (AR) is a member of the epidermal growth factor (EGF) family.  AR is an autocrine growth factor and functions to regulate cell proliferation and survival through binding the EGF receptor (EGFR).  AR promotes the proliferation of neural stem cells and epithelial cells, including keratinocytes and mammary epithelium. Up-regulated at puberty, AR promotes ductal outgrowth and mammary branching. In the liver, AR functions as a mitogen and prevents hepatocyte apoptosis.

*Single-unit price. For inquiries about this product, contact your sales representative.

Product 5 μg $9025 μg $207100 μg Inquire500 μg Inquire1Mg Inquire

Human Interleukin-31 (IL-31)
300-244P

 Interleukin 31 (IL-31) is an immunoregulatory cytokine that is expressed by activated type 2 T helper (Th2) cells.  IL-31 signals through a heterodimer receptor consisting of the IL-31 Receptor A (IL-31RA) and the oncostatin M receptor (OSMR), which are expressed on monocytes, epithelial cells, and keratinocytes.  IL-31 promotes allergic reactions and inflammatory skin diseases. 

Ships ambient. Store frozen at -20 to -10C.

*Single-unit price. For inquiries about this product, contact your sales representative.

Product 5 μg $9025 μg $207100 μg Inquire500 μg Inquire1Mg Inquire

Human Fibroblast Growth Factor-6 (FGF-6)
300-243P

Fibroblast growth factor 6 (FGF-6) is a heparin-binding growth factor that is expressed in epithelial and mesenchymal lineages. FGF-6 binds and signals through the FGF receptors FGFR1, FGFR2, and FGFR4. FGF-6 functions as a mitogen for vascular endothelial cells and fibroblasts. FGF-6 is also an important factor driving muscle differentiation and regeneration.

Ships ambient. Store frozen at -20 to -10C.

*Single-unit price. For inquiries about this product, contact your sales representative.

Product 10 μg $9050 μg $207100 μg Inquire500 μg Inquire1Mg Inquire

Human Fibroblast Growth Factor-5 (FGF-5)
300-242P

Fibroblast growth factor 5 (FGF-5) is a secreted heparin-binding growth factor that binds to FGF receptors 1 and 2 (FGFR1 and FGFR2). FGF-5 is expressed in the mesenchyme, skeletal muscles, central nervous system, and hair follicles to promote cell differentiation and proliferation. FGF-5 functions as a regulatory factor during hair elongation and skeletal muscle development.

Ships ambient. Store frozen at -20 to -10C.

*Single-unit price. For inquiries about this product, contact your sales representative.

Product 100 μg $90250 μg $207500 μg Inquire1Mg Inquire

Human Apolipoprotein-E4 (APO-E4)
300-241P

Apolipoprotein E (APO-E) is a chylomicron lipoprotein that is necessary for the metabolism of lipoproteins and lipid transport.  The APO-E gene has three alleles, termed APO-E2, APO-E3, and APO-E4.  The APO-E allelic proteins differ by only one or two amino acids, but have different biological structures and functions.  APO-E3 is the most common and neutral allele.  The APO-E4 allele is associated with an increased risk for Alzheimer’s Disease (AD) and coronary artery disease (CAD).  The APO-E4 protein morphology decreases the ability of APO-E4 to clear beta-amyloid

*Single-unit price. For inquiries about this product, contact your sales representative.

Product 5 μg $9020 μg $207100 μg Inquire500 μg Inquire1Mg Inquire

Human WNT1-inducible-signaling pathway protein-2 (WISP-2 / CTGF-L)
300-240P

WNT1-inducible-signaling pathway protein 2 (WISP-2) is a member of the CYR61/CTGF/NOV (CCN) family of regulatory factors. WISP-2 is expressed in ectodermal, mesodermal, and endodermal lineages, including primary osteoblasts, fibroblasts, mesenchymal stem cells, and adipogenic precursor cells. WISP-2 is a canonical WNT ligand that regulates cell proliferation, adhesion, and metastasis. Secreted WISP-2 promotes mesenchymal precursor cell proliferation and maintains them in an undifferentiated state.

*Single-unit price. For inquiries about this product, contact your sales representative.

Product 20 μg $90100 μg $207250 μg Inquire500 μg Inquire1Mg Inquire

Human IL-1 Receptor Antagonist (IL-1 RA / IL-1F3)
300-239P

  Interleukin-1 receptor antagonist (IL-1RA) binds the interleukin 1 receptor (IL-1R) to antagonize interleukin 1 alpha and beta signaling.  IL-1RA is secreted by immune cells, epithelial cells, hepatocytes, and adipocytes to inhibit IL-1-induced inflammation.  IL-1RA therapy is used to treat auto-inflammatory diseases such as diabetes and rheumatoid arthritis. 

Ships ambient. Store frozen at -20 to -10C.

*Single-unit price. For inquiries about this product, contact your sales representative.